Lance and Loretta are having a torrid affair behind her husband Howard's back. The problem is that Howard is brutal thug who is bound to catch the cheating pair sooner or later. To solve this problem, the lovers hatch a plan involving the Stackpoole family: a collection of misshapen freaks who waylay unsuspecting travellers and dissect them in gruesome experiments. Unfortunately, things don't go quite according to plan.
The cast includes three Sioux who were present at the actual event in 1876 that the film is based on. The producer had hoped to gain historical information from them, but said later that "the most we could get out of them was that the fight was over so quickly that they could remember little about it."