All the smart kids at St. Vincent Barbarino High School are mysteriously disappearing. In order to find out the cause, Stripperella must go back to school and pose as a student. She discovers the evil Dr. Cranium, a science teacher at the school, is having his students build a giant pa-pier mache' volcano in order to destroy the city, and he's getting rid of any kid that might be smart enough to foil his plan.