Nicola (Luigi Lo Cascio) and Matteo (Alessio Boni) Carati are two brothers of Rome, who live the years from 1966 to 2000 and all the events which have signed this period. They begin their adventure, helping Giorgia (Jasmine Trinca), a young girl confined in an asylum. Then, after the flood of Florence, Nicola meets Giulia (Sonia Bergamasco) a talented piano player with a dangerous sympathy for the BR. Alessio, a rebel spirit entered in the police, will find the optimistic photographer Mirella (Maya Sansa). These four characters and many others will cross the years of terrorism and Tangentopoli.