Ezra Powell, a renowned pioneer in the field of medical research, collapses in his lab. House is struggling after the ketamine treatment wore off and doesn't want to talk about it. When the team put Ezra through rigorous diagnostic tests and don't come up with anything conclusive Ezra demands the team to help him end his life. Now the team goes through twists and turns of the moral dilemma of ignoring his wishes or to assist in his suicide and abide by Ezra's wishes.