All of the interns are in awe when a woman comes in with a record breaking tumor, but it is so far advanced that the woman's prognosis is not good. Now that Bailey knows about Meredith and Derek's affair, their jobs are in jeopardy, and she strongly advises Meredith to end it. Meanwhile, Cristina and Burke's secret relationship gets more complicated, and when no one else can be reached, Izzie has to perform a major procedure on her own.