Keaton stars as Daphne Wilder, a mother whose love knows no bounds or boundaries. She is the proud mom of three daughters: stable psychologist Maggie (Lauren Graham), sexy and irreverent Mae (Piper Perabo) and insecure, adorable Milly (Mandy Moore) - who, when it comes to men, is like psychotic flypaper. In order to prevent her youngest from making the same mistakes she did, Daphne decides to set Milly up with the perfect man. Little does Milly know, however, that her mom placed an ad in the onl